发给老马备查:/ ~& s0 u2 e* y( g8 }
滴水察海(69304838) 15:23:239 M: z3 s& ?* T: g7 v
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱% }+ B% U! u6 O8 c4 z0 a* O% I
吉非替尼和S-1连用的依据
7 R) |9 ] }. X2 F2 sGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
0 A& _$ \: }1 M% G- r) ?是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
" l d) Q6 i4 M. h; H" }这样是不是推理出,耐药后,可以用S-1和培美了?
$ }2 b G1 K8 j9 x: n. X结论:
* C4 d5 k; b. t- [, {! P如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |