发给老马备查:
% x4 W) N# O, J9 g6 b滴水察海(69304838) 15:23:23
i8 T5 `# I5 X7 k老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
; k8 n+ c; ^9 |3 ~) m8 b吉非替尼和S-1连用的依据
& M! A0 n1 U4 F/ d! l- ~6 m: NGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.1 v$ q, k* F/ g- Q1 R+ M- s5 d: |5 n& d# J
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
4 r W: Z. q: o# X这样是不是推理出,耐药后,可以用S-1和培美了?2 O3 m, g4 A& D" |+ G# {3 j
结论:
% B6 B) q/ r) \如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |